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ADDISON`S DISEASE


Adrenal hypofunction from primary disease (partial or complete destruction) of the adrenal gland with inadequate secretion of glucocorticoids and mineralocorticoids. An autoimmune process is the most common cause (80% of the cases) followed by tuberculosis. AIDS is becoming a more frequent cause.;Addison`s disease (primary adrenocortical insufficiency) is differentiated from secondary (pituitary failure) and tertiary (hypothalamic failure) causes of adrenocortical insufficiency (see Differential Diagnosis);Addisonian (adrenal) crisis - acute complication of adrenal insufficiency (circulatory collapse, dehydration, hypotension, nausea, vomiting, hypoglycemia); usually precipitated by acute physiologic stressor such as surgery, illness, exacerbation of co-morbid process, acute withdrawal of long term corticosteroid therapy

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